The San Pedro, Los Angeles and Salt Lake railroad brought new traffic to the little crossroads community. The whistle-stop on the railroad time tables was designated as “Nippeno Camp”. Passengers bringing freight and cattle from the neighboring region traveled to Nippeno Camp as it was the most accessible railhead for transit to the east-Salt Lake City and Chicago, and to the west-Los Angeles.
By 1910 the S.P., L.A., & S.L. line had been merged into Harriman's Union Pacific Railroad System and the name of the crossroads community had been changed to Nipton. A stage coach line from Searchlight, Nevada was established to carry passengers and freight to Nipton and the railhead. Early records from the 1900 Census indicate an individual named Karns registered as a Mining Engineer in the Vanderbilt District. Post Office records for the period of 1907 – 1909 show a S.D. Karns as the Postmaster in Nipton. Voter records (1908) indicate that Karns was a registered voter in the Vanderbilt Precinct and worked as the storekeeper in Nipton. Obituaries in Pennsylvania papers indicated that Karns died in Nipton in 1909.